Four fire engines and around 25 firefighters tackled a fire at a terraced house on Belgrave Road in Walthamstow.
Most of the first floor was damaged by the fire. One man was rescued from a flat roof by firefighters and was treated on scene by London Ambulance Service.
Control Officers took the first of six calls at 2212 and the fire was extinguished by 2305. Crews from Walthamstow, Leyton and Leytonstone fire stations attended the scene.
The cause of the fire has been recorded as undetermined.