Eight fire engines and around 60 firefighters have been called to a warehouse fire on Bolina Road in Rotherhithe.
Part of a first floor mezzanine level of a mid-terraced industrial warehouse unit is alight.
Station Commander John Broadfield is at the scene, he said: "There are trains running nearby as normal despite some smoke on tracks.
"Local residents are advised to keep windows and doors closed due to the smoke."
One of the Brigade's 32-metre turntable ladders was used as an observation tower to provide the Incident Commander with an aerial view of the fire. The Brigade's drone team were also in attendance.
The Brigade's 999 Control officers received the first of 13 calls about the fire at 0800 and mobilised crews from Old Kent Road, New Cross, Deptford, Dockhead, Bethnal Green, E Greenwich, Greenwich and Dowgate fire stations. Crews remain in attendance.
The cause of the fire is not known at this stage.