Six fire engines and around 40 firefighters tackled a fire at a semi-detached house on Eagle Road in Wembley.
The first floor and roof were destroyed by the fire. There are no reports of any injuries.
One of the Brigade's 32-metre turntable ladders was used as a water tower to help fight the fire from above.
Control Officers took the first of nine calls at 1826 and mobilised crews from Wembley, Park Royal, Northolt and surrounding fire stations to the scene. The fire was extinguished by 2024.
The cause of the fire is under investigation.