Four fire engines and around 25 firefighters attended a fire on Manning Road in Dagenham.
A caravan was destroyed by fire, along with half of a car. A second car also sutained partial damage as well as the exterior of an outbuilding.
There were no reports of any injuries.
Firefighters safely removed two gas cylinders and cooled them to an ambient temperature as a precaution, as some cylinders can explode when exposed to heat.
The Brigade received the first of 31 calls about the fire at 2308 and Control Officers mobilised crews from Dagenham and Barking fire stations to the scene. The fire was extinguished by 2356.
The cause of the fire is under investigation by the Brigade and the Metropolitan Police.