Four fire engines and around 25 firefighters were called to a house fire on Curwen Avenue in Forest Gate.
A small part of the ground floor was damaged by fire. Five people left the building before the Brigade arrived and there were no reports of any injuries.
The Brigade's Control Officers took the first of three calls to the fire at 1256 and sent crews from Leytonstone, Plaistow, East Ham and Poplar fire stations to the scene. The fire was under control by 1320.
The cause of the fire is under investigation.