Four fire engines and around 25 firefighters tackled a fire at a range of garages on West Ham Lane in Stratford.
One garage was destroyed by the fire. There are no reports of any injuries.
Control Officers took the first of 11 calls at 2137 and mobilised crews to the scene from Plaistow, Leyton, Leytonstone and Stratford fire stations. The fire was extinguished by 2220.
The fire is believed to have been accidental.