Six fire engines and around 40 firefighters tackled a fire at a derelict bungalow on Old Church Lane in Perivale.
The bungalow was destroyed by fire.
The Brigade received the first of 18 calls about the fire at 0248 and Control Officers mobilised crews from Ealing, Park Royal, Acton, Wembley and Northolt fire stations to the scene. The fire was brought under control by 0355.
The cause of the fire is under investigation by the Brigade and the Metropolitan Police.