Four fire engines and around 25 firefighters tackled a fire at a school on Clark's Road in Seven Kings.
An external storage area was destroyed by the fire. A small part of a single storey building used as a preschool was damaged by the fire. There are currently no reports of any injuries.
Control Officers took the first of five calls at 0045 and mobilised crews from Ilford and Dagenham fire stations to the scene. The fire was extinguished by 0151.
The cause of the fire is under investigation.