Four fire engines and around 25 firefighters attended a fire at a flat on Midhurst Gardens in Hillingdon.
Half of a third-floor flat was damaged by fire. There were no reports of any injuries.
The Brigade received the first of 17 calls at 2222 and Control Officers mobilised crews from Southall, Heathrow, Feltham and Ealing fire stations to the scene. A 32-metre turntable ladder from Wembley Fire Station also attended. The fire was extinguished by 2317.
The cause of the fire is under investigation by the Brigade and Metropolitan Police.