Twenty fire engines and around 125 firefighters have been called to a fire near Vallentin Road and Shernhall Street in Walthamstow.
The fire has affected one house, multiple gardens and sheds as well as a railway embankment. Crews have been working hard to extinguish the fire as swiftly as possible.
The incident produced a significant amount of smoke at its height. People in the area were advised to keep their windows and doors. This advice has now been lifted.
Motorists are advised to avoid the area, including Wood Street, Shernhall Street and surrounding roads, as road closures are in place.
The Weaver Overground line has been partially closed. Transport for London service updates can be found here.
Two rest centres have been set up locally for residents affected by this incident in partnership with Waltham Forest Council.
The Brigade received the first of over 100 calls at 1827 and Control Officers have mobilised crews from Tottenham, Bethnal Green, Walthamstow, Chingford and surrounding fire stations to the scene.
A 32-metre turntable ladder is also in attendance and has been deployed as a water tower to help extinguish the fires from above. The Brigade's drone team are also on scene, providing the Incident Commander with a greater situational awareness.
The cause of the fire is unknown at this time.