Six fire engines and around 40 firefighters are responded to a fire at a hotel on Empire Way, Wembley.
The fire occurred on the second floor, in a building of 13 floors. Around 150 people evacuated the building before crews arrived.
The Brigade received the first of 29 calls reporting the fire at 1234. Control officers mobilised crews from Park Royal, Willesden, Northolt and surrounding fire stations to the scene. Firefighters were able to bring the fire under control by 1321.
The cause of the fire is under investigation.