Four fire engines and around 25 firefighters tackled a fire at a semi detached house on St Helier Avenue in Morden.
Most of the ground floor and first floor were destroyed by the fire. Five people left the building before the Brigade arrived. There are no reports of any injuries.
Control Officers took the first of 14 calls at 1313 and mobilised crews from Mitcham, Wimbledon, New Malden and Tooting fire stations to the scene. The fire was extinguished by 1343.
The cause of the fire is under investigation.