Four fire engines and around 25 firefighters attended a house fire on Barley Lane in Goodmayes.
Part of the second-floor was damaged by fire. The property was safely evacuated before firefighters arrived and there were no reports of any injuries.
The Brigade was called at 2334 and Control Officers mobilised crews from Ilford, Dagenham, Hainault and Barking fire stations to the scene. The fire was brought under control by 0006.
The cause of the fire is under investigation by the Brigade and Metropolitan Police.