Eight fire engines and around 40 firefighters tackled a fire at a car body repair workshop on Waterloo Road in Cricklewood.
The fire destroyed one car and affected part of the ground floor of the unit. There are currently no reports of any injuries.
Control Officers took the first of three calls at 0017 and have mobilised crews from Willesden, West Hampstead, Finchley and surrounding fire stations to the scene. The fire was under control by 0122.
The cause of the fire is under investigation.