Twelve fire engines and around 80 firefighters were called to a warehouse fire on Water Road in Wembley.
Firefighters tackled a fire at an industrial warehouse where part of the ground floor was destroyed. There were no injuries reported
Residents in the area were advised to keep their doors and windows closed due to the smoke, they are also advised to avoid the area as road closures were in place causing traffic disruption.
The Brigade's Control Office took the first call at 0218 and sent fire crews from Park Royal, Wembley, Willesden, Acton and other surrounding fire stations to the scene. The fire was under control by 0407.
The cause of the fire will be investigated.