Six fire engines and around 40 firefighters were called to a fire at a block of flats on Kilburn High Road, Kilburn.
The ground floor entrance hall was destroyed by the fire. One man was rescued from the third floor using a turntable ladder. A woman was rescued via an internal staircase using a smoke hood. A further five people were led to safety by firefighters wearing breathing apparatus. Four people were taken to hospital by London Ambulance Service.
Control Officers took the first of two calls at 1005 and mobilised crews from North Kensington, Willesden, West Hampstead and surrounding fire stations to the scene. The fire was extinguished by 1200.
The cause of the fire is under investigation.