Ten fire engines and around 70 firefighters responded to a fire at a waste facility on Transport Avenue, Brentford.
Around 60 tonnes of household was alight. Crews will remain on the scene into the evening, working to dampen down the pile and extinguish remaining pockets of fire.
The Brigade was first called about the incident at 1543, with crews from Heston, Chiswick, Southall and surrounding fire stations mobilised to the scene. Firefighters had the incident under control by 1804.
The cause of the fire is not yet known.