Eight fire engines and around 60 firefighters were called to a fire at a mid terraced shop with dwellings above on Great West Road in Hounslow.
Around half of the roof was destroyed by fire. There are no reports of any injuries.
The public were advised to avoid the area at this time as traffic was impacted by the fire.
Two of the Brigade's 32-metre turntable ladders were deployed to the scene to help fight the fire from above.
Control Officers took the first of two calls at 1523 and mobilised crews from Heston, Southall, Heathrow, Ealing, Hayes, Hillingdon and Kingston fire stations to the scene. The fire was under control by 1653.
The cause of the fire is under investigation.