Six fire engines and around 30 firefighters responded to a fire on Collins Way, Erith.
The fire was located in a semi-detached house of three floors. The buildings roof has destroyed by the fire and collapsed. The second floor of the property has also been destroyed as a result of the roof structure failing. One of the Brigade's 32m ladders was deployed to the scene to help firefighters tackle the flames from height. There are no reports of any injuries.
The Brigade was first called about the incident at 1250, and crews from Bexley, Erith, Greenwich and surrounding fire stations were mobilised to the scene. Firefighters had the incident under control by 1436.
The cause of the fire is not yet known.