Eight fire engines and around 60 firefighters were called to a fire at an end-of-terrace house on Roe Way in Wallington.
Part of the roof of a three storey house was destroyed by fire. One cat called Tiger was rescued by crews and brought to safety.
One of the Brigade's 32 metre ladders was deployed.
Station Commander Ian Simpson was at the scene, he said: "Traffic in the surrounding area was severely impacted. Motorists were advised to avoid the area."
The Brigade's 999 Control officers received the first of 15 calls reporting the fire at 1549. Firefighters from Wallington, Croydon, Purley, Sutton and Norbury fire stations were at the scene. The fire was under control by 1936.
The cause of the fire is under investigation.