Six fire engines and around 40 firefighters attended a fire at a recycling centre on Devon Street in South Bermondsey.
The fire involved a large pile of household waste. There were no reports of any injuries.
The Brigade was called at 2145 and Control Officers mobilised crews from Old Kent Road, New Cross, Peckham, Dockhead, Deptford and Dowgate fire stations to the scene. The fire was brought under control by 2319.
The cause of the fire has been recorded as accidental.