Six fire engines and around 40 firefighters attended a fire on Sunny Bank in South Norwood.
A commercial unit, situated within a row of four single-storey units, was partially damaged by fire. There were no reports of any injuries.
The Brigade received the first of eight calls at 2251 and Control Officers mobilised crews from Woodside, Beckenham, West Norwood, Croydon and Norbury fire stations to the scene. The fire was brought under control by 0003.
The cause of the fire has been recorded as undetermined.