Eight fire engines and around 60 firefighters were called to a fire at a residential building on Wornington Road in Kensal Town.
The fire occurred at a seven-storey block of flats. A flat on an upper level has been destroyed by fire, with some partial damage to the exterior of the building. One person was assessed at the scene by London Ambulance Service as a precaution.
Station Commander Scott Thorpe, who was at the scene, said: "The Brigade will keep a presence in the area into the evening, supporting local residents and providing fire safety advice. Our Fire Investigation Team are also present carrying out an investigation into the cause of the fire.
"Some disruption may still be expected on Wornington Road and Golborne Road whilst we remain on scene."
The Brigade received the first of eight calls about the fire at 1546 and Control Officers mobilised crews from North Kensington, Paddington, Kensington and surrounding fire stations to the scene. A 32-metre turntable ladder has also been in attendance and deployed as an observation tower, providing the Incident Commander with a greater situational awareness of the fire.
The fire was brought under control by 1644.
The cause of the fire is under investigation.