Eight fire engines and around 60 firefighters responded to a fire on Thurlow Gardens, Wembley.
A commercial property consisting of a single floor was involved in the fire.
The Brigade received the first of over 30 calls reporting the fire at 1709. Control Officers mobilised crews from Park Royal, Willesden, Northolt and surrounding fire stations to the scene. Firefighters had the incident under control by 1823.
The cause of the fire is not yet known.