Ten fire engines and around 70 firefighters tackled a fire at a warehouse on St Thomas Road in Belvedere.
Half of the single-storey warehouse was damaged by fire. There are currently no reports of any injuries.
Station Commander Lee McCauley said: "Crews have made steady progress at the scene of the fire to bring it under control, a small part of the warehouse remains alight and crews will stay at the scene into the evening.
"There are multiple road closures in place in the direct vicinity, which are likely to cause disruption for a number of hours.
"The fire is producing some smoke and we urge people to avoid the area where possible and keep windows and doors closed if you live or work nearby."
One of the Brigade's 32-metre turntable ladders was used as an observation tower, providing a vantage point for the incident commanders to assess the incident and develop tactics.
The Brigade's Control Officers took the first call to the fire at 1417 and mobilised crews from Erith, Plumstead, East Greenwich, Greenwich, Sidcup and surrounding fire stations to the scene.The fire was brought under control at 1808.
The cause of the fire will be investigated by the Brigade's Fire Investigation Unit.