Four fire engines and around 25 firefighters tackled a fire at a semi-detached house on Harold Road in Park Royal.
Most of the ground floor and part of the first floor were damaged by the fire. A car was destroyed by the fire. There are no reports of any injuries.
Control Officers took the first of fifteen calls at 0041 and mobilised crews from Park Royal, Acton, Willesden and Wembley fire stations to the scene. The fire was extinguished by 0249.
The cause of the fire is under investigation by the Brigade and the Metropolitan Police Service.