Eight fire engines and around 60 firefighters were called to a building fire on Battersea Park Road in Battersea.
The fire has been affecting a three-storey building with commercial properties on the ground floor and flats above. Two flats on the second floor, along with part of the roof of the building, were alight.
The fire has now been brought under control by firefighters but crews will remain on scene over the coming hours to fully extinguish the fire and to dampen down.
There have been no reports of any injuries at this time.
People in the area were advised to keep their windows and doors closed at the height of the fire due to smoke travelling from the incident.
Battersea Park Road remains closed between the junctions of Queenstown Road and Havelock Terrace. The incident is causing significant traffic disruption and motorists are advised to continue to avoid the area whilst firefighters remain on scene.
The Brigade received the first of 17 calls about the fire at 1428 and Control Officers mobilised crews from Clapham, Battersea, Lambeth, Brixton and surrounding fire stations to the scene. A 32-metre turntable ladder from Clapham Fire Station has also been in attendance and used as a water tower to help extinguish the fire from above.
The fire was brought under control by 1555.
The cause of the fire is under investigation.