Ten fire engines and around 70 firefighters tackled a house fire on Hale End Road in Walthamstow.
One terraced house was destroyed by the fire. A small part of the roof of four neighbouring properties was damaged by the fire. One man left the building before the Brigade arrived. There are no reports of any injuries.
Local residents were advised to keep their windows and doors shut due to smoke travel in the area.
The fire is believed to have been accidental and was caused by a toaster.
A London Fire Brigade spokesperson said: "Avoid keeping items such as toasters under cupboards or in contact with combustible items such as tea towels or kitchen roll to prevent heat build-up.
"It's also important to make sure you keep toasters clean to help prevent fires.
“Firefighters also recommend that you have a look at our online Home Fire Safety Checker to make sure there are no hidden hazards in your home.
“The online tool will ask you a series of questions that will help us work out the level of risk in your home, or the home of someone you care for. It only takes a few minutes to get tailored advice to keep yourself and loved ones safe from fire.”
One of the Brigade's 32-metre turntable ladders was used at the scene as a water tower to help tackle the fire from above.
Control Officers took the first of 13 calls at 1019 and mobilised crews from Walthamstow, Woodford, Leyton and surrounding fire stations to the scene. The fire was under control by 1341.