Fifteen fire engines and around 100 firefighters were called to a fire involving a mixed-use building on Wood Lane in White City.
The fire affected the top floors of the nine storey building, a restaurant, external decking and ducting were alight and damaged by the fire. A number of flats were also affected by the fire due to smoke and water damage. One person was treated at the scene for smoke inhalation by London Ambulance Service crews.
Station Commander Graham Beers said: "Crews have been working hard all day in challenging conditions to bring the fire under control.
"This was a complex fire at the top of the building and firefighters worked tirelessly to prevent the fire from spreading. Two 32-metre turntable ladders attended and were deployed as water towers to help extinguish the fire from height. The Brigade's drone team also attended, providing the Incident Commander with a greater situational awareness of the fire.
"It is expected crews will remain at the scene of the fire throughout the evening."
The Brigade worked alongside multi-agency partners, including the Metropolitan Police, to evacuate around 22 residents from the building and buildings in the area were evacuated as a precaution. A rest centre was set up for residents who were evacuated from their homes.
The Brigade was called at 0308 and Control Officers mobilised crews from Hammersmith, North Kensington, Kensington, Chiswick and surrounding fire stations to the scene. The fire was brought under control at 1701.
The cause of the fire is under investigation by the Brigade's Fire Investigation Unit.