Four fire engines and around 25 firefighters attended a fire on Commercial Road in Shadwell.
Rubbish and shrubbery, situated on an area of disused land between two buildings, was alight. There were no reports of any injuries.
The Brigade received the first of 11 calls at 1508 and Control Officers mobilised crews from Shadwell, Bethnal Green, Poplar and Millwall fire stations to the scene. The fire was extinguished by 1624.
The cause of the fire is being treated as accidental.