Ten fire engines and around 70 firefighters responded to a fire on Rochester Row, Westminster.
A sixth-floor flat was destroyed by fire. One man was rescued from a seventh-floor balcony using a 32-metre turntable ladder and was assessed on scene by London Ambulance Service crews. A further 23 people left the building before the Brigade arrived.
Two of the Brigade's 32m ladders were deployed to the scene, alongside the Drone Team.
The Brigade received the first of 23 calls reporting the fire at 1950, with Control Officers mobilising crews from Lambeth, Soho, Paddington and surrounding fire stations to the scene in response. Firefighters were able to bring the fire under control by 2132.
The cause of the fire is under investigation by the Brigade's Fire Investigation Team and the Metropolitan Police Service.