Four fire engines and around 25 firefighters tackled a fire at a terraced house on Wetherell Road in Homerton.
Half of the ground floor was damaged by the fire. There were no reports of any injuries.
Control Officers took the first of six calls at 0358 and mobilised crews from Homerton, Shoreditch and Leyton fire stations to the scene. The incident was over at 0541.
The cause of the fire is under investigation.