Four fire engines and around 25 firefighters tackled a fire at a terraced house on Brookfield Road in Hackney.
Most of the ground floor was damaged by the fire. Five people left the building before the Brigade arrived. There were no reports of any injuries.
The fire is believed to have been caused by the failure of lithium-ion batteries for an e-bike.
A London Fire Brigade spokesperson said: “E-bikes and e-scooters are a green and sustainable way to travel around our city. However, e-bikes and e-scooters can pose a significant fire risk and particularly the batteries used to power them have become one of London's fastest-growing fire risks. They have destroyed homes and families have sadly lost loved ones in these fires. From our investigations, we know many of the fires we’ve attended have involved second-hand vehicles or the bike has been modified using parts bought online.
"If you own an e-bike or e-scooter, there are a number of things you can do to help keep yourself and those around you safe. It is vital that you do not store or charge the device on an escape route such as a hallway. We have seen incidents where people have had to jump from windows or be rescued by firefighters because their escape route has been blocked by fire or smoke. If it is not possible to keep the device outside or in a shed or garage, make sure it is in a room where you can shut the door and contain a fire.
"When charging your e-bike or e-scooter, make sure you are using the correct charger. Mismatching the charger increases the risk of fire. It's also important not to overcharge and to unplug the charger once it's completed charging. Never charge an e-bike or e-scooter unattended or whilst your sleeping. If you're converting your bike from a pushbike into an e-bike, make sure you get a professional or competent person to carry out the conversion."
Control Officers took the first of two calls at 0251 and mobilised crews from Homerton, Leyton and Leytonstone fire stations to the scene. The fire was extinguished by 0337.