Twenty-five fire engines and around 150 firefighters tackled a fire at an industrial estate on Maypole Crescent in Erith.
A single-storey warehouse in a scrap yard was alight, along with three diggers and numerous vehicles. There were no reports of any injuries.
Two 32-metre turntable ladders were deployed to provide a vantage point for assessing the scene and to deliver water from above.
One of the Brigade's fire boats was also mobilised to the incident. The boat has two remote-operated water monitors which can pump 2,500 litres per minute, to help with firefighting operations from the Thames.
Assistant Commissioner Pat Goulbourne said: “Our crews have been working hard throughout the night at a large fire on an industrial estate in Erith. While the fire is now under control, we continue to tackle some areas of waste material that are still alight.
“Firefighters remain at the scene and its likely they will be there throughout the day. The estate and the nearby roads are closed and we advise residents or those who work at the site to avoid the area.
“Residents are also advised to keep their doors and windows closed as there is still a lot of smoke in the area.”
The Brigade's Control Officers took the first of 12 calls to the fire at 2247 and mobilised crews from Bexley, Erith, Plumstead, East Greenwich, Sidcup and surrounding fire stations to the scene. The fire was under control by 0652.
The cause of the fire is under investigation.