Ten fire engines and around 70 firefighters were called to a fire on Richmond Road in East Twickenham.
The fire mostly involved a three-storey mixed-use building. The roof and second floor was damaged along with part of the first floor and ground floor. Three neighbouring properties were also partially damaged along with an outbuilding. Firefighters remain on scene dampening down hotspots.
One man has been taken to hospital.
The fire was producing a large amount of smoke and people in the area were advised to keep windows and doors closed.
Road closures remain in place, including on Richmond Road, which is causing significant traffic disruption. Please continue avoid the area at this time.
The Brigade received the first of 34 calls at 1638 and Control Officers have mobilised crews from Richmond, Twickenham, Chiswick, Acton and surrounding fire stations to the scene. A 32-metre turntable ladder from Clapham Fire Station is also in attendance and is being used as a water tower to help extinguish the fire from above. The fire was brought under control by 1820.
The cause of the fire is under investigation.