Eight fire engines and around 60 firefighters have been called to a fire on Heron Crescent in Sidcup.
The roof of a two-storey derelict building was fully alight. Part of the first floor was also damaged by fire. There were no reports of any injuries.
Local residents were advised to keep windows and doors closed due to large amounts of smoke being produced.
Drivers were warned to expect some traffic disruption in the area, including on Main Road.
The Brigade received the first of eight calls at 1331 and Control Officers mobilised crews from Orpington, Bromley, Lee Green and surrounding fire stations to the scene. A 32-metre turntable ladder from Greenwich Fire Station has also been in attendance and used as a water tower to help extinguish the fire from above. It has also been deployed as an observation tower to provide the Incident Commander with a greater situational awareness of the incident, along with a drone. The fire was brought under control by 1548.
The cause of the fire is under investigation by the Brigade and Metropolitan Police.