Eight fire engines and around 60 firefighters responded to a fire on York Street, Twickenham.
The fire was located in a building consisting of a commercial space with flats above. Parts of the ground and first floors in the building have been damaged by the fire. Two of the Brigade's 32m ladders were sent to the scene to support firefighting operations. There are no reports of any injuries.
York Street is closed between Arragon Road and the junction with the A310 and A305 whilst crews remain on scene.
The Brigade received the first of six calls reporting the fire at 1041, and Control Officers have sent crews from Twickenham, Richmond, Heston and surrounding fire stations to the scene. Firefighters were able to bring the fire under control by 1256.
The cause of the fire is under investigation by the Brigade's fire investigators.