Four fire engines and around 25 firefighters tackled a fire at a shop with dwellings above on High Road in South Woodford.
Most of the first floor and part of the second floor of the four storey building were damaged by the fire. There were no reports of any injuries.
The Brigade was called at 1247 and Control Officers mobilised firefighters from Woodford, Leytonstone, Walthamstow and Leyton fire stations to the scene. The incident was over at 1437.
The cause of the fire is under investigation.