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Six fire engines and around 40 firefighters tackled a house fire on Cornwell Gardens in Leyton.
The fire badly damaged the first floor and part of the second floor.
A man left the property, uninjured before the Brigade arrived.
The Brigade was called at 1058 and the fire was under control by 1209. Firefighters from Leyton, Leytonstone, Walthamstow, Stoke Newington, Poplar and Tottenham fire stations were at the scene. The cause of the fire is under investigation.