Four fire engines and 21 firefighters and officers were called to a fire at a shed in Poyser Street, Bethnal Green.
A timber shed attached to a house was destroyed by fire. Half of the house's first floor and roof was damaged in the blaze. Four people left the house before the arrival of the Brigade.
The Brigade was called at 0600 and the fire was under control at 0736. Fire crews from Homerton, Islington and Dockhead fire stations attended the scene.
The cause of the fire is under investigation.