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Six fire engines and 35 firefighters and officers were called to a fire at a garage in Mogden Lane in Isleworth.
A range of brick and timber garages were damaged by fire. Approximately 50 people from neighbouring properties were evacuated as a precaution.
The Brigade's 999 control officers took a total of 22 calls to the fire.
The Brigade was called at 1322 and the fire was under control at 1508. Fire crews from Heston, Twickenham, Richmond and other nearby fire stations attended the scene.
The cause of the fire is under investigation.