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Firefighters were called to a road traffic collision on Jerrard Street in Ladywell.
One motor bike and one bus were involved in the collision.
Firefighters released a man on the motor bike who was trapped. Sadly he was pronounced dead at the scene.
The Brigade was called at 1001 and the incident was over for firefighters by 1111. Two fire engines from Lewisham fire stations and one fire rescue unit from Bethnal Green fire station attended the scene.