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Ten fire engines and around 70 firefighters were called to a fire at a car workshop on Hoe Street in Walthamstow.
The ground, first floor and roof of a car workshop and garages were destroyed by the fire. There were no reports of any injuries.
Station Commander Jon Holt, who was at the scene, said: "Crews worked hard to protect the surrounding shops and businesses and stop the fire spreading."
The Brigade’s 999 Control Officers took 25 calls to the fire.
The Brigade was called at 1657 and the fire was under control by 2001. Fire crews from Walthamstow, Leyton, Tottenham, Woodford and Homerton fire stations were at the scene.
The cause of the fire has been recorded as undetermined.