Fifteen fire engines and around 100 firefighters were called to a fire on Lancing Road in Croydon.
A single-storey car workshop and a shipping container were destroyed by the fire and a transit van was damaged. A small part of the first floor of a neighbouring detached house was also damaged by the blaze. There were no reports of any injuries.
Crews also cooled a number of argon, propane and acetylene cylinders as some cylinders can explode when exposed to heat.
The Brigade's 999 Control Officers took 39 calls to the fire.
The Brigade was called at 1744 and the fire was under control by 2151. Fire crews from Norbury, Croydon, Mitcham, West Norwood, Brixton, Addington and surrounding fire stations were at the scene.
The cause of the fire is under investigation.