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Four fire engines and around 25 firefighters were called to reports of garages alight on Mile End Road in Mile End.
Two single-storey garages were damaged by fire. There were no reports of any injuries.
The Brigade was called at 0739 and the fire was under control by 0807. Fire crews from Bethnal Green, Whitechapel, Poplar and Shadwell fire stations attended the scene.
The cause of the fire is under investigation.