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Four fire engines and around 25 firefighters were called to a fire at a house on Priory Close in Hayes.
The ground and first floor of an end of terrace house were destroyed by the fire and part of the loft space was also damaged. There were no reported injuries.
The Brigade was called at 1530 and the fire was under control by 1638. Fire crews from Hayes, Southall and Heathrow fire stations attended the scene.
The cause of the fire is under investigation.