Four fire engines and around 25 firefighters were called to a fire at a shop with flats above on High Road in Leytonstone.
Part of the ground floor was damaged by fire. Nine adults and a child left the property before the arrival of the Brigade. There were no reports of any injuries.
The Brigade was called at 0103 and the fire was under control by 0235. Fire crews from Leytonstone, Leyton, Stratford and Walthamstow fire stations attended the scene.
The cause of the fire is under investigation.