Six fire engines and around 40 firefighters were called to a fire at a house on Bridge Road in Slade Green.
Most of the ground floor and first floor of the semi-detached house were damaged by the fire. There were no reports of any injuries.
The Brigade was called at 1442 and the fire was under control by 1551. Fire crews from Erith, Bexley and Plumstead fire stations, along with colleagues from Kent Fire and Rescue Service, attended.
The cause of the fire is under investigation.