Four fire engines and around 25 firefighters were called to a garage fire on Sumner Road in Croydon.
Around half of the garage was damaged by fire, which destroyed one car inside. The fire spread to trees and destroyed a nearby garden shed.
The Brigade was called at 0018 and the fire was under control at 0244. Fire crews from Croydon and Norbury fire stations attended the scene.
The cause of the fire is under investigation.