Four fire engines and around 25 firefighters were called to a fire at a garage and office on Leyton Road in Stratford.
The second floor of an office block was destroyed by the fire. Fortunately, there were no reports of any injuries.
The Brigade was called at 2218 and the fire was under control by 2346.Fire crews from Stratford, Leytonstone, Leyton and Plaistow fire stations attended the scene.
The cause of the fire is under investigation.